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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3981485c1f49a43ebc25f9bf2c8db5b9df8cd99467cb69c2ab26b50619ec3915' 
  AND token = 'vGkz3tXEKi0zOEMqT3AZ/4yeVbnrQ48/CzXNPB0crz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}