SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6223f578129e5e4887f1a90226a331a438e8d043f3b339817259e00df1c0ada8' 
  AND token = 'lsqooBC1Ruo4Z+b8uWt13GFkWMN4z4BGIvtjQlU+4Ek=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}