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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9cd618bd149fc09c17ce42d834964e1a0c9054a9517245978ee3a9a260a65ec8' 
  AND token = 'E5/pDZVwcY3z6jpb+FmyGs1nc+3C9QEyBnGCcFwxZHc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}