SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e2b980ccff011117ff7bc88f3372863c4259fa3201e4a5ae84b211968e5d729' 
  AND token = '2wa6zlQWMukaEk+DiImTgPPVtDXAguyr0rSREQYHMos=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}