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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '157e6c95d47fde06d2a42e99b3a8b162bb4744ff24efd3f317ced66f65a71239' 
  AND token = 'SOmjMkS/wk80wT+z/aoyM8JE0tYmi9tYfV0nUwZUkJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}