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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1dc10d836cd8932a9490b32a7f20ae7d58cfa373da009748e9c061fb691cd88b' 
  AND token = 'CPyxbsDV9/AlMsnKc6YjfIpFwkRYYlNaEWknjhLX/i4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}