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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781fff5b5cbabb99700a325ae13e1a59ccb67579b0a92b7b5c6e6f807a07719a' 
  AND token = 'hCofmArITYu0mu1czLMcpNTMevWZIyH8VPggYOAOyNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}