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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a49a84977599a1e9fb52f11b13fceaf3d45c9188ba0f13e9516fea1e581f2d21' 
  AND token = 'quNWeBYVX4DIrnXtJkSlLnagGbpj1kPnzMSTz6zQPJo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00062

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}