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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c5bc321fa8f965d0f627a36d3c8df0c33f052658ab1dc8fde0c9955335c4113' 
  AND token = 'DjWvMlOOFw3j0kh4sGChVJSxuGt3cmx1EbSGA0UvQYU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}