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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e7c2ba9ecf60bc28836f52e393f5df4574af052ad7a801f07fd43f44ce2b247' 
  AND token = 'gMVWnio/nFu4UUmwW0Twhx/FyDdDmWGKLDsFdXIiNsU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}