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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9b4c80f66e8df21cae590acfd7f3115465939a2a40357298c4b8e7d73679ce80' 
  AND token = 'O2i603MkdR8IGrhLTmINNBUsHBcN/vzAs4V0oQQGV2I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}