SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43148761f5bde173a06d0ed456878fcdd571f9881c251c67de05917929a90178' 
  AND token = '2NgCP++VWumzsfBmn4Kg5lG6ZAv2xxmMvk9Igtr7pkY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}