SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e16c6c8f3acd2ebd4d40f874091a18fd3f26fcacaf782f8b0453aca041e4004' 
  AND token = 'jTrbtCkEFcDsxfVKEcpDLfJu36P6ylPS+ZwmFOsA1sI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}