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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e48827d2365415e65d99230bc651a8b69c482bde34cedaa96dd2031a49093c7c' 
  AND token = 'U3rqqw/BzQQLL//6IIHc4khPbqAKWjqLuJlIndfbx00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}