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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72e224f78039cccdc65b2d761af0dd990aac0b43e135eeeb3e1e91c1c37c0594' 
  AND token = 'WcRGBJAArnH7s2amcsUJqT/NHitVEhDRdHOgEMcgzBM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}