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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e999bfa1f76436925cf909f610f420c3896d8d8bc8b55870644efafb02c0be1' 
  AND token = 'tU77A1MplkSZf0lPEX6pgAkmWUeiV/aY5VOQ6zg+n+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}