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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '86d1488b20c07a17134634e266444a4f0e2127b9f027e4c1c2061ca345388f3b' 
  AND token = 'UIUMY2kIs75DHS65hMEvs5IvG3cTHOiQ4YqwM/ADiII=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}