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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59c0c70efd562f2e1235c6c870cb626eba0f2e2c88418e6c2049cfa75594a610' 
  AND token = 'rQ5jMvcTLMIBCRPUrr7IO3MQdp8hHZnHru9ImT9zbnk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}