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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50a4dc7155b1533b17476693f641adedb038bde84395367bdc52da095f43182d' 
  AND token = 'EtRMXFafjWQI88+FkaORQP4no74rXsRcWgruTkGw60w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}