SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b33e0ddd4d1925649e37c9357a457c765decc2c50e4cbb305af1ee7151a06eb' 
  AND token = 'CDlT2PQWwee587xOC2GG1Dc0Pyt3aKMkwoQSLn1uaY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}