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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21052864bf1f265c756e35f4062a43d790d34689f92af24da516447b222686f3' 
  AND token = 'jcP/Gtq1vhKi53iOMdGl6a3CWj/aw8ddPmN57Tr6p/c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}