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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d665d1fd3f304cc6bf7712f095549d283bf7cf2dc31236e475d1b16fe52e19' 
  AND token = 'cto1tRP5PVHjH8LRZHyhBw4Bayvk0VvZb9/5oUByFR4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}