SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65101a585b4d5aa5997c5b186fbcb2e6f9ee5abe20f5e75cc444c173005751c1' 
  AND token = 'yKwj7dyG0P2ACNKd+TkKat0qakklweaTKXK4sl7hXVs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}