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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8f8158b1e6a75b9400e74b75d1c1d181cb29499f5272883b3bb27d88a096845' 
  AND token = '1AB0nLfI9DPSYSTmDha0mdgDVEMxs5BLfhyrwV4EvlY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}