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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d7676b5a038075d058e71b9cd99396ef0cad4e5fa57d686940949c1f1018c49' 
  AND token = 'tUQwomR4A2SqA+HceOPZTXTfdNyEi2Hy+lXxFxQQECc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00066

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}