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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9d01ba774fb60cc77eda1b338b0e53bfbc01fea487ad743733e6aaf5055bc049' 
  AND token = 'wpfzYZsfQFC+imxeR8F6G1IWiQdiqMkcxj/xnXNEuOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}