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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de40b1c114d4a394a4a496e32457e313d81311f6250a2ac8fff3d7ca35bf1a53' 
  AND token = 'G9n0I5ysEEd3hy7Vcfiusxb+b5QkZbhG3EGyKnrivKU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}