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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ae314d381d14b1aabaef6cf29977cd49b325c28e543da941ebf23b401d18b9' 
  AND token = 'JG4ugHmSO8WymV5BDT8hMmWiDK0qgD2VKkkjSP40WDI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}