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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8180103916bd9dd9ab8bbff31fcf188044f8f082be76b92016ce45ee72f9f397' 
  AND token = '+tjtCrBEMgI1Ak4JhVdxj0b7TXciEkuIp6aUmSFoYMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}