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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6fe0733198e8860bd02e51a53cf7ce3d9a7af18961c39ea3cc7114187226a822' 
  AND token = '249few0+P8DCz+2lVQp7G5u+A4+hR2ighUBoKfLAMPw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}