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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '078f24d1a3db6136dc05dd608587042c322797db9b52a8fd229f5cec1ff5aea0' 
  AND token = 'eQ+nKubmqpc7x1KgDnERQ8yi1pOIXGKzvKTtVcm4QgQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}