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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8644efaf8704298d9b08e2f0d5d8a7c251ed22465ab2907ad56faf61f2c5f127' 
  AND token = 'iOPMcaO+nFc6iCygH/xF9XHUh8Lok3Vo51g0iL0m+A0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}