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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4046531828b0a8fed96ea042d52cfa077f9d9e8f95c8b69b36f064657e5921c4' 
  AND token = 'kO14LwpcitF0pwR5zL4mZ/PHV0+GaZcLVI0ZkpRpv8I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}