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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c497156c2b4f771a341df9716b46b0061f87fa43a12d46ef1a4e1fe903724ba' 
  AND token = 'eqar1I9KZ0q8bhukl/sAE8bGq3m4CSJXZ5sXRqjZ3UQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}