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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d2d727ccbc2cb0b7a89ad246188772c8bf21343397698b8d03bda56fe830a7d' 
  AND token = 'H4/tPMX+kc5LWrQkOR+a8eylOTYELFWCt+ebrVTxZwU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}