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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f6a1dd6afdb4b124af0498a1f2d8887846c79c1fe736ee094ffdb52f959114' 
  AND token = '6cyu8wwo5bCY9TPZ5STN70+5rGLTIXK1LBcj2gDgrQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}