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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e4e780c455dbcc81b98c35df85041d2748113d1cbce86110581d5b069f9135b' 
  AND token = 'PLIUPWLgQMObvS4vE2aTZV4dNhNWLHHOWb7v5XnNkf8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}