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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0a981d6ad235f05cf60bf050e7fd9cd5bd4ed863207891cb0b45cd96ddacae59' 
  AND token = 'aOX31Poo0GOlZZztPUfKR8/WjwcT0eT4L9d1Pm2gHdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}