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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33c226955c591d9a68f59de2f1bab59cfed1a1b8d3e40bf1a7e41abb4dedeada' 
  AND token = 'OmHPz7d+eNfX0atk1I1WWXvigDkXnAY4VBZzCOowVwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}