SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '492233fa2c1959bf1b704d6042e12e164f71aea97dd32d13090e9410c29544df' 
  AND token = 'm03JxZBS0NViyZ6g1YPmDxKfL/K9g+SHdRqeydsd2sA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}