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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72243ecb1f831b234af2bb2bf7bc32414433b640aff4ffb15ed3cb0bb62783cc' 
  AND token = 'gUttmUAlDra/ondvYB+Yf1JSW4qsT/A0mZf3KUz8L+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}