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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54e56382078b3c6547dc0e231fdbe4e2ac9fbfcfeac5035a1a7045a2012e8d9f' 
  AND token = 'FfX2qelscK2kUjqaI++X/DxvDNMCLuUcQcMCKuzlJY4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}