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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b0d1d4eb49b27b0ec43970cb9331c5883fc96d7c71e62ba12d4fea33144afa8' 
  AND token = '6qnFWKCn2y9/9h1zsU4qWdXCroVmEfVJ0qFHPes2Sgk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}