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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01000220af1469d4bb17c4b7b6a9a71f5a595e2afea0b965bfb34625de54f737' 
  AND token = 'zj847XNXr33MJN3iyz/419n3kOmsE3aejZcbc57IFuw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}