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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a5e8a0b3341b65100597100f7dd0f493b9f3954f704e052de9821b1d825823a' 
  AND token = '99cTcYVP1TMExBxo1v847metiFpd46Uwp49k5PRZVpA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}