SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729d8dbfe7059324558a1adf78e55ff5016805a217efcc29c2023603ad30806a' 
  AND token = 'MKSkP7kyBJqQw8Ie/plni12CnJrHhkZuxo0yl4bT0Rg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}