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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e7751e49d2107cc040e4543750ffcf414a9cff94ed45ee490f6ea8d9ea4725e6' 
  AND token = 'Ehea8Mhz+e9Wc2ZaATsH1oRql1RY9Y9B+m1lFiCPVww=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}