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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fa0c3883bc1a6551250f85b0482181bc0c46ecf45a100a2a8611f91bd1b0bc0' 
  AND token = 'q5eOUchMxHoHMu+Ty2EEx1k8h74L/HrUBIZ9GueRAO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}