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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c004a27e59ff01488ee72feb786bf1740bd7b420f184b47916b3f98796a809d' 
  AND token = 'UQMxt/zz1hHxlTYciCWPjCPAozJ1dGJsMDLLIDDgMo8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}