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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '35330229727c9565b68d9ce46f54a1747a173c450ad85843e4a3f0b170b2e3a8' 
  AND token = '9HRqD+fNUDdG2zMAVu8+e/jf1dyOZuRiNsXr2z1nkOQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}